How does selling on vestiaire work
A Place To Share Your Music
2012.06.19 23:00 A Place To Share Your Music
A subreddit for new and upcoming musicians to share their music and a place for listeners to discover, give feedback and support new bands & Solo Artists. 🎤⚡️for classical shareyourclassical
2009.06.14 12:00 epicRelic Resumes
A place for people to give and receive resume-related advice.
2011.07.14 12:04 IAmAnAnonymousCoward shadow ban admins mods hell
Find out if you are shadowbanned and what to do about it. shadow ban admin mod hell moderator removed invisible banned help check
2023.05.28 15:50 DrGinge01 Run out sensor Ender 3 S1 Pro using Creality Cloud
I am getting an error message every time I print a model on my Ender 3 S1 Pro using reality cloud. For about a month, it worked great and had no errors, and then all of a sudden, it started. I press the button acknowledging that I have read the message and it continues to print. The blue light on the sensor is on indicating it has filament and when I remove the filament it goes off. So it looks like the sensor is working. Any ideas on how I can reset creality cloud?
Thanks again in advance. I read some messages from a couple of years back indicating that they had the same problem with no solutions posted. Hoping someone has figured it out.
submitted by DrGinge01
to 3Dprinting [link] [comments]
2023.05.28 15:49 GatorEatsBiggerNmbr Recruiter is ghosting after reaching out - AITA?
2023.05.28 15:49 Ruff_Magician Building inspection failure
Ok so I bought an apartment back in February but I didn't move in to it straight away as I was working away. I had a building inspection done and everything was fine with the property. Just prior to settlement, I had a pre purchase inspection done and again everything was fine. But I've just moved into the apartment this week and the oven doesn't work. I've gone back and read the building inspection report and it states that the oven is working but after looking at the pictures, you can see that only the hob is working and the oven has no lights showing on the front so it obviously wasn't working when the inspection was done. What id like to know is, what should I do next? Is there a recourse for me? I've paid for an inspection, the picture in the inspection shows that the oven isn't working but the report states that it does. Can the building inspector be liable for fixing it?
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to AusProperty [link] [comments]
2023.05.28 15:49 SnooCalculations5521 How does Corporatism work?
I've read it groups all workers of the same profession/category under groups where they decide the price of things, the conditions etc. But i'm not sure if i fully understand how it works. Would the state control those groups? Would they have a leader? Would they be democratic? I think corporatism is the least spoken economic idea and i'm pretty curious to investigate about it since it's the system which most fascist states used
submitted by SnooCalculations5521
to FascismReclaimed [link] [comments]
2023.05.28 15:48 CoAtchB Bag setup
I’m working on my bag setup. What clubs does everyone use?
Just curious as I am someone new to customizing clubs in a golf game.
submitted by CoAtchB
to EASportsPGATour [link] [comments]
2023.05.28 15:47 bunkabinks I don't know how to talk about this, but today my journal just won't do.
I don't really know where to start either, so I guess I'll start by saying I am a survivor.
Through no one's fault that lived in the house I grew up in, our childhood was very difficult. It was chaotic, turbulent, and often we had no running water. Our Parents split up when I was very young and there were periods of time where my father was simply not in the picture and my mother was more often than not in her room, so my siblings and I mostly managed that time on our own. When my mother pulled herself together and managed to raise us mostly alone, she attended college and earned her degree, becoming a special education teacher. As you can imagine, raising 4 kids on a teacher's salary, one with with severe disabilities, was incredibly hard for her to do. While my father did pay child support, he didn't make anywhere near enough to really help and his contributions was hardly enough to buy food for a month. Although I'm incredibly proud of my mother for working so hard to earn her degree, it was simultaneously the best and worse thing that could have happened to us. We had been receiving help from our state for my special needs sibling, and with her new job, we lost all the aid we had been getting for him and insurance refused to cover anything we had for him before the change. Things went downhill the years that followed and without going too deep into the details, cps was involved as the situation was becoming too dangerous for us all and my sibling was taken as a ward of the state. My father at that point has cleaned himself up and had been much more involved in our lives, but very early into my teen years he had to move away from us to find more work, and my relationship with my mother had become sour due to our resentments toward each other, so by the time I'd met him, I was desperate for any amount of love or attention.
I met him in while in a dark period of my life, my high school sweetheart, my ex-husband, he was my rock. I felt like he was the only person that held any interest in me, that would talk to me and listen to what I had to say, and he always knew how to make me feel better. But things didn't seem right to me, he would often talk badly of my family, but I was so angry and hurt at the time, I'm sure I didn't paint them in the best light so I didn't think anything of it. He would want me to do things with him, even when I was uncomfortable or tried to refuse, but I'd always give in eventually because I was afraid to lose him. He'd make comments about my body and make me feel like I was unworthy because of my body hair and my shape and I thought I was ugly. He'd broken up with me at one point without any explanation and only tried to date me again after I'd started dating someone else. When we did get back together, I tried even harder to keep him, and that's when I should have known what was actually happening. His comments came up more, he was more aggressive about what he wanted, and while at that point he had never hit me, he made me sleep with him when I said I couldn't do that/didn't want to. But I stayed because I didn't think anyone else loved me and I didn't know that what he was doing was wrong. My parents and I never talked about that kind of thing and my parents were single for most of my life up up until that point, and I didn't have step parents until I was in my late teens, so I didn't know that my experience was not normal in a healthy relationship.
As we grew older and graduated from high school I discovered that he had tried dating a girl I was close with and she warned me what he said and did so I broke up with him and started college on my own, only to learn we had the same psychology class and he pulled me back in. I wasn't doing well in school and tensions between my mother and I had only gotten worse, so when his parents offered for me to move in with them, I jumped at the opportunity. The only rule being I had to go to school or at least be working, which I followed, but at that point he had quit school and was constantly either quitting jobs or just stopped going altogether, and started volunteering at a VFD, so I felt obligated to earn an income for us in order to stay so I quit school and stated working. I was never allowed to see our bank details, I was never given the login nor would he let me see the account so I never knew where the money was going, but I didn't complain because I had food, running water, clothes, and a roof over my head and that was enough for me. I know that it paid for the car insurance for his vehicle, and an awful lot of subway, but I don't know what else he spent the money on. Eventually I needed dental care, which my family and I had not been able to get much of, and he needed access to mental health services and my income was not enough to cover either of those so I married him and I joined the military as I felt I didn't have any other options. He was ecstatic, but my family took the news hard and it only caused more discourse.
After joining, things did not improve. I remember finishing up bootcamp and being so excited with how much money I would be earning, I thought we'd never have to worry about it again, and I was so happy to be able to provide for him in ways that I had not been able to before. I would be earning a free education, getting health care, and eventually maybe I could raise a family like I always wanted, but felt was out of reach for me. It was only after I graduated that I learned he spent everything. He only returned some items he had bought because one of my siblings found out and made him give some back. After the graduation he wanted to move to where I was training for my job, so he drove up with all our things and stayed in a hotel room close to base. As you can imagine, that was also very expensive. We eventually got housing, but we had almost nothing when we moved in. He got a job on base and would watch all the women as they did PT, would drink every night at home, and things only got more turbulent the longer we lived on our own. Eventually he quit his job and would drink all day and get upset with me when I'd come home from work because I was too tired to do much and I was struggling to keep up in training so I was studying late at the school house almost everyday.
Eventually our relationship broke down after I had made a horrifying discovery, something so terrible that I couldn't even look past it. At that point I had made up my mind that the marriage was over, I couldn't be with him anymore, and I left to stay with a friend for a few days. During this time I had made a terrible mistake and cheated on my ex-husband. Not because I wanted revenge, but because I wanted someone to care about me, even if it was for the wrong reasons, but it only solidified my decision. After building up the courage to go home and tell him everything, the cheating, that what he was doing was wrong, and that I couldn't take it anymore and that I wanted a divorce. I didn't even get a chance to tell him before he told me if I ever left him like that or ever tried to end the relationship he 'would be upstairs with a gun in his mouth'. He had never threated himself or others before this so I believed him and I ended up staying and keeping everything a secret out of fear of what he would do. I took apart the gun he bought with the money I had earned and hid them in different parts of the house to keep him from killing himself and I told him he needed to stop drinking, seek therapy, and either get a job or work on school/trade school, and I would seek therapy for myself. I asked for marriage counseling, but he refused and said he'd do therapy on his own. He only went to a few sessions before quitting. I went to receive services on base for my marital issues and as I started talking to a counselor, she made it very clear to me that what he was doing was abuse and she would not allow me to leave the building unless I filed some kind of report on him, and me not clearly understanding how reporting worked in the military entirely, panicked and filled a closed report on him so at least there was a paper trail. I never went back because I was in denial about the abuse and I did not think I was a victim, if anything I felt as guilty as him.
As my career progressed, things did settle down for awhile. I had finished up school and at that point we had moved to my first duty station, he was still drinking, but not as often and did start working again part time and I had started becoming more relaxed. I met the division I would be working with and I loved them all. They were the first real experience I had ever had with stability and it was something I needed. I became more of a workaholic, volunteering to stay later to accomplish more tasks as we were shorthanded and I wanted to be more helpful to the division. Things had been going well for the most part, but I was still deep in denial about things he was doing. He had taken out credit cards without telling me and even took one out in my name without me knowing, I only found out after they called me to apologize for the card being late and that it was on the way. I was so shocked I didn't correct her and he maxed out all the cards. I still had no access to the account, but at this point I could text the bank to get the balance, but still didn't know where the money was going. He started to be more aggressive about intimacy and demanding more and more of me, and there were times where I'd wake up to him touching me or he would just wake me up for sex so I wasn't able to sleep much and I was tired all the time. I didn't say anything or try to stop him anymore because I felt like I deserved it for what I had done, and it was easier to give him what he wanted than to try to fight him or make him stop. I was afraid of what would happen if I ever said no.
After this point in time, we finally had an idea of when I was to be deployed and things began to ramp up. I was away from home more often, but it was still several months away from deployment and with the holidays coming up, we decided to go big that year and make thanksgiving dinner. A few days after thanksgiving, I wasn't feeling well and was experiencing abdominal pain, but with my PCOS symptoms I just figured my cycle was coming and was hitting me harder than usual, but he recognized that something was wrong and made me go to the hospital and I had emergency surgery for my appendix. I remember him wanting to take a picture of my stomach because 'I would never look the same again', all I could think about before that was how scared I was of the surgery and how long it would take for me to go back to work, but after that it made me feel even more ugly as it was one of the only things he ever really said he liked about me and I felt vain for worrying about the scars. The surgery didn't go as planned, and instead of the small incisions I was told I would have, I woke up to a massive scar right down the center on my abdomen. My appendix had been too close to bursting and they had to make a larger opening to remove it, and all I could remember was the blinding pain as they wheeled me back to my room where I was left alone with him. I did not receive any pain medication for several hours after and it was the worst pain I'd ever experienced in my life. When they finally did give me something, it wasn't enough and I was put on Dilaudid to manage my pain. The second night of my week long stay, my husband was lying in bed with me and asked me for sex. I was in so much pain, all I could think about was how horrible I felt, and I said no to him for the first time in nearly two years. That I needed to get better first and I didn't think I could handle it with the pain I was in, but he kept touching me and begging, saying the Dilaudid would keep me from being in too much pain and I felt so scared that I said yes because every time before I had said no he took what he wanted anyway and I was afraid that he would hurt me. All I can remember doing was looking out the window and the night, watching the cars drive away on the the highway and the cars leaving the parking lot and as he pulled up my gown, and I pushed the button for more medicine, but it wasn't enough to stop the pain. I remember the visitors I had after, I remember my division getting me flowers and a get well soon card with so many kind words that I kept all this time and all I could do was push the button for more medicine, but it still hurt so much. I had to walk after and every day to keep clots from forming and to start recovering, but my pain never diminished and I was discharged from the hospital.
In the months that followed my pain changed and seemed like it was spreading, but it never stopped hurting, sometimes it wouldn't be so bad, but others were so bad I couldn't get out of bed. He was still asking for sex and other favors, but with less frequency as he seemed more frustrated that I couldn't preform. Every time I had to, I was in so much pain I could not function at home or at work and it affected me very deeply. We tried getting help for my pain and to try and figure out what was going on, but all the doctors I saw accused me of drug seeking behaviors and wouldn't offer me any help or send me to someone who could help me. It got so bad that I started begging them for help and begging them not to give me anything until we knew what was wrong, all the while deployment was fast approaching and I was afraid that I would either miss the deployment, or that I would go, but still not know what was wrong and drag my division down. I became very depressed and started drinking as we made more appointments. I remember the 3rd or 4th time they sent me to gyno for my issues I had become so frustrated and angry that I laid everything out with the doctor, every single little thing I could think of I told them (all with the exception of my ex husbands treatment) and she didn't ask me any questions, she didn't ask me about the details of my many symptoms at this point, or try to understand how I was feeling. She instead asked me how my relationship was with my father was. All the while he was sitting in the room with us, the real cause to all my pain in aguish, just casually listening in, waiting to complain how I wasn't having enough sex with him as he did in most of the appointments and I became enraged. I defended my father, and I put my uniform back on and said I'd like to speak with another doctor and asked her directly how to file a report, not against my ex, but her for saying something so horrible about my Dad, the only man in my life I loved more than any other in the world. After I left I called to make another appointment as I couldn't see anyone else that day.
When I was finally sent to pain management, deployment was two months away and I was terrified. I wanted to go so badly because it meant I could get away from him, I could finally leave him and he would never be able to reach me so long as I was on the ship and safe with my division, but nothing worked out the way I had hoped for. I was told it was Fibromyalgia. That this condition was life long and there was no cure, that I'd not only be removed from the ship, but that I'd have to leave the military all together. I was devastated, and the little patience he did give me while we tried to get a diagnosis quickly disappeared. I was put on several different medications to manage my symptoms, but he continued to make me have sex, even when we were told not to so I could have a chance to let my body recover, and things got worse the more I pushed back. The medication was meant to help me sleep because my pain could be better managed if I slept better, but he would wake me up at night and hurt me, and it never stopped. One night, when I was on Ambien, I had gone to bed and I remember falling asleep next to him, but I woke up to him on top of me, inside me, it hurt so much and I was in so much pain and it was so dark I didn't recognize him. I tired to fight him off me, but the medicine was so strong I couldn't stop him and he pinned my arms down. I couldn't stop crying and he finally stopped. I can't remember if he finished or not because I fell back asleep crying and flaring up. He continued this kind of behavior for the months that followed and although he never went that far again, he did continue to make me have sex and continued to hurt me in my sleep to the point of waking me up, claiming he loved me too much to stop. I didn't feel safe enough to take Ambein anymore and eventually stopped it all together, I didn't sleep for 4 days after that. All of this was happening as I was removed from the ship and placed on limited duty orders to await my medical board, placed in therapy, physical therapy, and many other appointments and medication changes to try to get my symptoms under control, but things became harder for me to manage and my drinking only got worse. When I finally escaped him, with the help of my now husband, I stopped all treatments and medications to manage my symptoms. To this day I cannot bring myself to be in a hospital, doctor's office, or take anything other than the things I took as a teen because I know how they work and that I can defend myself when I take them.
I can't bring myself to write anymore tonight, but there were so many things that happened that it's too much for me to write it all down and while I know he did many terrible things, I also was not innocent and I broke my vows. I will never defend myself for cheating, I know it was wrong and to this day I punish myself for it, but I do not regret finally learning that sex was not something you take from someone you love, that it was not something that is forced on you, it's not supposed to hurt you. Rape is not a consequence for cheating, you might destroy your marriage, you might end a relationship or somehow work it all out and stay together, but you do not deserve to go through that even when you make such a terrible mistake. If they can do so many awful things and you stay with them, forgive them, and still try to make it work, why give them so much grace and not give yourself even the smallest amount? You are a human being who is deserving of love and dignity, you do not deserve abuse. If anyone reads this please know that if you feel alone, if you're in this situation still, know that I love you and that when you are free, things will get so much better for you I promise. You are worthy of love and your deserve better.
submitted by bunkabinks
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2023.05.28 15:46 Short_Crow_9739 I have a huge crush on my manager.
He won't be my manager for much longer, so I'm wondering if I should ask him out after I move on to my next role.
He's a good looking guy, not striking or typically my type, but I've grown really fond of him. I catch myself sometimes making it obvious I like him. The way I look at him or talk to him. (Which is kind of embarrassing lol) I think he likes me too but I'm wondering if I'm reading him wrong.
We work in a very professional setting. So there isn't any flirting, but we do often have personal conversations about our lives. That's why I've come to like him I absolutely adore his personality. We laugh a lot, we talk about things we love, things we hate, things we struggle with, we swap life advice and insight. Etc.
On the work side of things. He's the best manager anyone could have. He is so supportive of everyone in our group. He is always there for us. He allows us to make mistakes and corrects us but in no way to make us feel like we aren't good enough. He's just encouraging. He does take time to get to know everyone in our group. So I don't know if i could be reading signals wrong and he talks like this with others. I wouldn't know because we all have our individual time with him to talk about work or our lives.
So that's it. I'm in no way ready to date but I am wondering if I should ask him out on a friend's basis, after I move on to my next role... Like to offer to take him out as a "thank you" for being such a great manager. Or if I should just let it be, give him a gift and wait and see what happens when I move on.
If anyone could provide any advice I would really appreciate it.
submitted by Short_Crow_9739
to Advice [link] [comments]
2023.05.28 15:46 Low-Trick-2637 You only know you love her when you let her go
There's this girl (21F) who liked me (26M) when i was at my lowest point of my life. She liked me a lot but i pushed her away.
We met during pandemic and it was really a tough time for me; i have a family problem, career problem and midlife crisis. It is so bad that we have to get out of my father's house and live with a relative temporarily, she was a girl next door and thats how we met. We have the same circle of friends in the neighborhood and we slowly got to know each other. When face2face work set-up started i was able to get a job and she continued her schooling in the same city that i work. We dated after a while and found out we have a lot of things in common. She wanted me, but i have lots of problems and i dont want her to carry my burden. I am depressed and i cant give her the love that she deserves for i dont even have enough to give to myself. I confronted her that it would be best for her to find other guys; it hurt her but during that time i felt less pain than she did because she liked me more than i liked her. Now we are still friends and we are moving on with our own lives but a part of me wants her back.
Things are getting good now but i think it would have been better if only i kept her. As days went by i realized that i actually have feelings for her, more than i thought. My mood always gets gloomy but she always chases the clouds away. She is moving on now and im happy for her. Im praying for her happiness even if im not a part of it. I miss her a lot but i think is goodbye for us. I found a job in a city far from here and i might not see her for a long time. It was a wrong time for us but if we ever meet again i hope theres still a chance. So im saying goodbye for now, my silver lining, my rainbow, my Sun.
submitted by Low-Trick-2637
to OffMyChestPH [link] [comments]
2023.05.28 15:46 broncobama_ Teacher, looking to transition to private EdTech. What's wrong with my resume?
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to resumes [link] [comments]
2023.05.28 15:46 raiadi REVIEW NEEDED - E-commerce platform for social media sellers
Page Link: www.linkzyp.com
If you have ever purchased from a Instagram seller you must have noticed a few issues in this whole system of buying and selling from a social media influencer.
Let me breakdown a few problem which I have seen. 1. Frauds:
There have been way too many frauds to count. Scammers ask you to DM them and once you pay money there is no response. 2. Trust:
We don't even know if the user has been selling good products. We don't have buyers review. We are not sure if the sellers is legit. 3. Billing and payment:
You don't even get the bill of the order placed or payment for the product is not as smooth as possible. 4. No product link:
On platforms like Instagram if you find a reel/post of a product and you like it. It's hard to find the same on sellers page because there is no link.
You can list more problems if you know of any.
So what do we do about it. My team is working on a platform to solve these problems. We will create a trust score for every seller based on the orders they fulfil and custormer reviews. To solve the problem of no link on platforms such as Instagram we will create 4 character code for example AB3C which can be used to search a product on sellers page immediately.
Now if you are a seller make sure you checkout www.linkzyp.com
and register for early access. We will be launching soon.
If you are not please provide a feedback for the landing and what can be improved about this whole idea.
submitted by raiadi
to SaaS [link] [comments]
2023.05.28 15:46 MGK_2 I Tell You A Mystery
| || | submitted by MGK_2 to LeronLimab_Times [link] [comments]
Welcome here folks. It becomes a little too obvious to me on what is going to happen. It is not if, it is when. Let's reveal the thinking on why I say this. It all goes back to the Mystery on the 2022, mid-summer daydream run up. We are living in strange times. You don't need me to tell you that. From the surface of it, it appears as if we are going to hell in a handbasket, it is almost as if we are about to fall off a cliff, however, that hasn't happened, at least not yet. I get it, though at times, it may seem that I don't. The things we have experienced holding this stock are not normal, but neither are the times.
In the long term, Leronlimab shall become the CCR5 blockade of choice, the Gold Standard. That shall happen. It will be written into the medical journals and text books as the monoclonal antibody which cured humanity of HIV and shall become the standard of care in NASH and metastatic malignant tumors. Many of us here already know that this shall happen. So, I wanted to know more about Leronlimab and to explore LL, you need to know CytoDyn and this page was born.
Both myself and a buddy of mine who you also may know, u/psasoffice
come together on occasion to lay down the dirt on what it is. Today then becomes another instance of yesterday's conversation. I say this to say that in much of what follows, I am the messenger. The bike messenger who picks up the package, reads it while I peddle along, and then deliver it to you soon after the discussion. And let me tell you, u/psasoffice
puts together the pieces, a puzzle master where no plot or twist is beyond his x-ray vision. As a matter of fact, He has been behind much of what I've written for over the past 6 months now; it might have been since October or even September of last year, when he sent me something which peaked my interest indicating that he liked what I was putting down, and then it just kept expounding. You can see what I've written here
, but somewhere around this post
, that I began talking with u/psasoffice
and many of the articles has his influence.
There were many indications or hopes set that hold will lift by a certain date. That didn't happen. It has been my notion, (not necessarily u/psasoffice
's notion, but it may be), that when we see that Peace and Safety become of concern, then it shall be then when the hold lifts. Well, next week, America may default on its debt so then, the markets could quiver. That could lead to unrest. What I've said is that when there is rampant havoc & distress all around us, and the masses screaming for some Peace and Safety, so it is then when things begin for CytoDyn. I said it before, that when this time arrives, we best remain still, stalwart, confident and quiet. We have seen the signs of where we are headed, and know, we are there. We have taken the exit off the highway and are nearing our destination. Therefore, when the strong winds blow, take a strong, solid and stout stance and know, that this moment was just one of the reasons why you bought your shares. This Initiating Juncture and the events which follow the triggering event of lifting the hold are not that far off, but rather, they are right around the corner. Actually, we have reached the destination, so get out of your car, take a breather and stretch. Shut your engines off. We are there. We did it. We've reached that point. Patience is a virtue. I sincerely appreciate all of you on this difficult journey together.
We have been living the same day again and again, like its Ground Hog Day over and over. All of us have been under the impression that all has been done. That all has been submitted. We understand that no more than 30 days should pass from the day the last submittal was sent before a Result is issued. However, we have the same lack of result day after day. Such a grueling process, what does all of this mean? It means that we have gone through the required process for so long and have paid a huge price, but despite becoming emaciated and haggard, we have finally arrived. Our heads were held under water by forceful hands for so long, fighting against our wills to survive, finding ourselves running out of air, finally, we break free from the strong grip and take that breath. Those still here after so long shall find the answer they seek since their desire for this answer is as much as their desire for that breath of air. Breath of fresh air is well worth the wait when forced underwater indefinitely, outside of your personal control.
Just 2 weeks ago, Cyrus took a leave of absence due to illness. Cytomight sensed he had something going on, but he probably was trying to stick it out, but in the end, he had to leave and now requires time to recover. Lets hope that when he is recovered and able to return, that the Result is already in by then; we already know that it shall be a positive one. Lets hope that on the day which he returns, that the NDAs, partnerships & collaborations which are all contingent on the hold being lifted have all or some, been already signed and activated, thereby allowing Cyrus to return as CEO. Wait! How can these agreements be signed if Cyrus lies in bed? Oh yeah, I remember now, we in fact do have an interim President Antonio Migliarese who is already versed in signing these agreements. I love the profound wisdom of this strategic team.
We recently got some awesome news in the way of CytoDyn's newly hired CMO, Dr. Melissa Palmer, who is nothing but a NASH specialist and long time expert in the field of Hepatology. Also, CytoDyn hired Dr. Salah Kivlighn, who has a rare blend of science and business acumen and has 15 years tenure at Merck & Co. What does that tell you? NASH is CytoDyn's #1 indication. Management at CytoDyn has been communicating that NASH is #1 on the docket for clinical trials since the time that Cyrus came on board, because it was his team which established NASH as having the highest revenue potential. Cyrus has been telling shareholders that NASH is to be CytoDyn's own, that is, without partnership, but this is becoming increasingly more difficult to adjudicate.
If CytoDyn does in fact have a clinical trial for NASH in design and development and in the running, then the Mystery of which I speak is, how does CytoDyn pull this off?
Lets look at some of the details. A Phase 2 clinical trial for NASH would be pretty expensive ($35-50 million) and large, (150 to 200 patients) and it could take 12-18 months before we see any results. In the 12/7/22 R&D Update, Management stated that they had hoped to initiate it by 3q 2023 and to be fully enrolled by end of 2023.
As a reminder of the 12/7/22 R&D Update Investor Deck found here.
: Slide 98
- 1:31: 40: So in terms of what potential time lines can look like, I think it's really important to highlight that from a value-creation standpoint, and I've mentioned this before, we truly do need to generate a large robust and what I call unequivocal data set that will leave no questions left on the table, right? And that a strategic partner would find attractive and attractive enough to do a real value-accretive deal with the company.
- 1:32:14: And so we've gone through and knocked out what the potential time lines are across each of the different areas that we presented on today. And we're -- as I mentioned before, NASH & Oncology are our priorities. However, because this is all going to be funding dependent, we're going to focus on NASH initially and work with co-development partners to the extent that we can to develop in oncology.
- 1:32: 44: So what do we expect in 2023? So our largest priority is the removal of the clinical hold in HIV. This is essentially a gating step for us to be able to get back to normal operations as a company and do what biotech companies do, which is advanced therapeutics and try to bring them to market.
- 1:33:10: Following the lift of the clinical hold, we expect financing to fund operations and to achieve this value inflection point that I've just alluded to. We intend on initiating a new NASH trial. We would like to commit to an investment in and advance longer-acting CCR5 molecules, as this is potentially the future of at least certainly HIV therapy, as Dr. Sacha presented.
- 1:33:35: We continue to contribute in medical meetings and peer-reviewed publications. Again, the CD02 trial data is in process for that right now. We're going to continue to reshape our team and our capabilities in order to meet our goals. And at some point following the achievement of earlier metrics listed on the slide, we're starting a corporate rebranding as well.
Now back to what I was saying about the large and expensive clinical trial for NASH. What about the problem of recruiting the patients? There is huge demand for these patients. There is a lot of competition here. NASH patients are like gold to enroll as so many Pharmaceuticals compete for those patents for their own NASH trials. How does a small Biotech, pre-revenue company with only $5 million in available funds pull this off? Not only paying for the trial, but how can it show itself as having the clout required to round up those patients in a rapid way? My feeling is a partneCRO needs to be involved somehow.
First off, we know for sure, that the NASH clinical trial will not be entered into until the hold lifts. Once the hold lifts, we can expect near immediate revelation of how this will be accomplished. But, we can speculate as to how this will get done. u/psasoffice
suggests that if we follow the money, we can find our answer. But you might ask, What money? We don’t have any. So then, what if we follow the share price?
Remember back to mid-summer 2022, when Cyrus was hired as President, share price was low and even fell following his hiring, but soon thereafter, in late July through August of 2022, the share price rapidly rose to $1.26 per share and then progressively diminished once again over the course of ensuing 6-9 months to where it is today.
Lets take a look at this so we can get to the secrets which will be revealed, where we can open the doors of the collaborations. You may ask, How did we get someone to accept a collaboration? When were the collaborations accepted? Along with Mazen Noureddin and Jonah Sacha, Cyrus presented the R&D Update Investor Deck on 12/7/22 and he was able to say all the things which were said then 6 months in advance and he said them essentially in a DEFA14A SEC filing.
The forecasts made in this document and in this presentation were filed with the SEC in an 8-K.
So then, how long before Dec 7 did Cyrus know that the very things which he would plan for the company which he wrote about in the Investor Deck were so very possible to file it with the SEC? Let's say he knew of the strength of his forecast say 1-2 months in advance. Therefore, by mid October he was aware of secret agreements, Cyrus must have known of specific collaborations which would allow those prognostic statements to be made in the Investor Deck, but which were predicated upon the hold being lifted. Therefore, How long did it take Cyrus and collaborators to sit down and make the agreements of NDA? Again, another 1-2 months? So by August, 2022?
Now you can see why the share price inexplicably rose in July / August, 2022. A Collaboration on a NASH clinical trial occurred which also explains the result of these words spoken on 6/30/22 Conference Call by Scott Kelly after his trip to EASL in London: "37:10 Scott Kelly: OK, so we certainly acknowledge being more metered and conservative in our publicity. We will be announcing important presentations and studies on a going forward basis. Regarding the NASH, about how NASH attracted partnerships, we just presented the PDFF and cT1 and biomarker data at EASL in London, just to shed some color on the importance of the EASL meeting, there were over 7,000 delegates present or online from 114 countries. There were 1,722 abstracts presented. There were only 4 poster presentations selected for a walking tour with the chairman at EASL. And We were one of those 4. I was present and I can tell you, it was well received by the scientific community. We can not comment on potential partnerships. But there are multiple opportunities for NASH and NASH HIV.
What also happened in August? Only the removal of the first management player who’s experience was in Negotiation and Partnerships, Brendan P. Rae. No longer any necessity for Negotiation? I guess not. As time went quickly by, without any word of what was taking place, the share price began to fall. It became uncomfortably obvious that by mid November, Recknor had been let go. He was CytoDyn's most experienced scientific, medical and managerial player for NASH, but in the game of a collaboration, anyone and everyone is a commodity and all are replaceable. On the same topic, a significant stock bonus was paid to the president in September of last year after only two months on the job. Was a deal struck? Also, our very own CMO, Scott Kelly who coined the phrase: “There are many ways to structure a partnership.“ himself gets terminated in December 2022. A CMO possessing far more experience in the #1 indication than he could ever have was already being eyed and prepared to take that role for the biggest proving ground party that will show that Leronlimab eradicates steatosis and fibrosis in NASH and NAFLD. Welcome Dr. Palmer.
Once the NASH deal was struck in July/August, it wasn't long before the share price began to rise but just as quickly, it fell as well. Rumors of a partnership must have gotten out, the price ran way up, but then later, in late August, down it went. The stock price dropped because there were no announcements by either party backing the deal. That’s due to the fact that it is contingent on the hold lifting and that it could be a year out before this collaboration moves forward. The collaboration was put on hold along with the clinical hold. It was not revealed outright and therefore, shareholders were not aware of it, but it still exists and therefore CytoDyn remains confident. It is not a traditional partnership, but rather a non traditional one which we may use to answer the questions of how can the NASH trial be funded and how can CytoDyn have the utter confidence to put together such a timeline for proceeding in such a large scale Phase 2 trial in NASH without possessing the necessary funds itself.
How then can we define a Non traditional partnership? CytoDyn will not get a large upfront payment. Instead, CytoDyn continues on its own, however, all the CRO work shall be done by our collaborator. What’s is in it for the collaborator? They run the NASH trial because they believe Leronlimab helps their drug get over the finish line. But Cyrus was saying NASH would be Leronlimab monotherapy and wouldn't be combination therapy. CytoDyn just can't go it alone, it is too small, and a hard luck story company which has failed in its history thus far at every turn. For NASH, u/psasoffice
is thinking GSK, while I'm leaning towards Merck.
All of us know that Leronlimab could do it alone in NASH, but that’s not how the Pharma game is played. CytoDyn needs help, and it has 4 different plays, and each play is devoid of a deep enough data pool which would bring in funding for that indication. Cyrus' long term goal is to build out a strong enough clinical trial data pool to present it to a partner or a buyer. So then, without any cash of our own, Cyrus' plan is to have someone else's funding, partner with CytoDyn and build for us that data pool and in the end, have exactly those same partners compete for the entirety of it, for the whole or part once that data pool is firmly in our grasp.
The same story goes for HIV-Prep and HIV-Cure which is probably being run by the 3rd party Research and Development Bio-Tech company Vir, in collaboration to develop the long acting or a more longer acting molecule of CCR5 blockade. Vir is pretty much a given with Scott Hansen's strong connections there. This was kept secret, but somewhat hinted at by Cyrus in the 4/11/23 Webcast
We can apply the same logic in the Oncology study being run by MD Anderson using Merck's Keytruda in combination with Leronlimab. We had all been waiting to find out what had happened with the results of the MD Anderson study, and Cyrus threw us this line: "Leronlimab is currently being trialed in combination with Keytruda (pembrolizumab) in a breast cancer xenograft model in partnership with MD Anderson Cancer Center.
" From here,
he gave us a hint of what is to come.
It can be assumed that as these collaborations are announced, there shall be share price inflection. In his astute fashion, Cyrus has given us the secrets, but, because of these strange times, the share price has not yet moved. But what it has done is it has held us here, because we are above the times. And we may be seeing a default on the debt in the coming week as well, but remember to remain strong.
CytoDyn knows its has a problem. Therefore, while our collaborators are running these trials for us, CytoDyn itself, remains detached as we pursue other similar non traditional collaborations. The perishable, flesh and blood CytoDyn uses the strategy of its intellect and the power of its IP to become the imperishable CytoDynasty. As Leronlimab has many, many, many indications, so shall CytoDyn have many, many, many collaborations. This is the direction until Merck goes up against GSK who bids against TAK
, (thank you Jake!!), for the likes of little CytoDyn who at that point, possesses the grand data pool which Cyrus coveted which was freely obtained in only a few short years of time well spent.
Oh Black Hole, do yourself a favor and swallow and regurgitate everything you just read. Where then shall you find your victory zzy? I see you stabbing yourself and choking on your own stinger of death. Cyrus spelled it out for you dumb ass. Watch it happen before your blind eyes and you still will deny it has even occurred. Oh, I hear it at the door knocking. But you are both deaf and blind. Why are you here? Only to be robbed and the longer and deeper you choose to remain here, the worse it will be for you. However, it is easily avoidable. Cut the short position and go long.
2023.05.28 15:46 Single-Nothing-3922 How can i interact with data in google sheets or other's to save, check and delete.
Basically i want to implement a registration and login system for my godot 4 game, i want it to save scores to have a leaderboard, the accounts can just be premade in sheets and im trying to figure out how can i add, save, delete in my game and update it in the google sheets data to save scores and player accounts.
I want it to check the sheets if the player has been registered or not. If the player has already been registered then the player can gain access and continue his score count
Im not really sure if it will work using google sheets and such
P.s: im a beginner at godot game development and I'm currently using the godot4 as the platform for my game. This game is a school project im working on and it emphasizes on database specifically on add, edit, delete. I chose this project to challenge myself as well as the fun of it and for my passion of game developing, im sorry to bother any of your time but any help for this is appreciated by me truly. Thanks in advance and i hope to keep working for y'all
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2023.05.28 15:46 Bm1542 Tips on home offer
Hello, I am looking at a house that was originally out of my price range but has dropped down now due to a failed septic and possibly a well issue. It's a beautiful property in a desirable area where homes are still selling within days of being on the market. This home, however, has been sitting for 2+ months and had the original buyer back out due to the failed septic.
Sellers dropped the price considerably over 3 weeks ago and still only got low offers on the house which they did not accept.
The septic repair will probably cost more than the max amount of sellers assist, so I had a lawyer draft up an addendum that will make the sellers cover all the expenses and there are many protections and outs for me in there if they do not do a satisfactory job or cut corners. I am comfortable with the legal language.
My realtor told me they are looking for around $585k and that the sellers already turned down low offers, but did not know what those offers were. I was thinking I would offer $575 + the addendum that ensures the septic and well are in good working order at closing.
My lawyer seems to think I am offering too much and says he has done thousands of deals over the years and thinks I am $40-50k too high even with them having to make repairs because typically a house sitting this long with bad septic is going to scare pretty much every buyer other than cash buyers with low offers.
Thing is this home is basically my dream property. It needs a lot of updating, but the property itself and house is exactly what I look for.
Any tips are appreciated
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2023.05.28 15:45 Wild-Difficulty-9780 Difference between Laney overdrive/boost
I couldn't find a similar post to this, so here we go:
I have been looking at those Laney Black Country Customs boost/overdrive pedals, to boost my Orange OR100, for sludgey post-metal and early Mastodon stuff. We're talking about the Tony Iommi TI-Boost, SteelPark and the Monolith. The Monolith seems to be a higher gain version of the Steelpark, but does anyone know the actual tonal differences between the TI-Boost and the SteelPark? It says on the website that they are similar, but the TI-boost is modified for Tony's needs, which doesnt really say anything.
So does anybody have any experience with how these two pedals compare? And does anybody know how the Monolith fares in a boost situation?
PS. Im currently using a Plumes and a BAT Skyboost to do the job with my Orange. Does anybody by any chance know how the Steelpark and the TI-boost compares to those, specifically i mean the Skyboost.
Thanks in advance.
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2023.05.28 15:45 throwaway28282828292 In-Laws Being Selfish?
My in-laws are asking my wife and I to come over and help them move furniture.
My wife is currently doing IVF injections and I feel that it’s selfish and unreasonable of her parents to even ask us to help given what we are going through without consideration to hire someone.
We are just going to help since we already committed to it. I will be the one doing the physical help, but I still find it annoying and want to see if anyone else would agree I’m not crazy for that feeling?
I also have some thoughts about how these kind of non-emergency requests to help may come up in the future as they get older and my wife does additional cycles, hopefully gets pregnant, etc. Plus we both work 40-50 hour weeks to begin with and are always busy.
I don’t think it’s unreasonable to help parents out, even in non-emergency situations. However, I am frustrated at this particular situation.
What should I do going forward?
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2023.05.28 15:45 PoorlyCutFries "Course reserved for 3rd year students in Co-op"
I've been looking through Carleton's public class schedule and I found that there is an ELEC 3909 section running this semester explicitly meant for Co-op students. Logically, it also is scheduled 6-9 to take place after normal work hours. What doesn't make sense to me is that the mandatory PA section (which according to online class outlines also does midterms) is scheduled at 2:30.
Does anyone know anything about this? How can a section meant and scheduled for Co-op students have a mandatory PA session that will almost certainly conflict.
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to CarletonU [link] [comments]
2023.05.28 15:45 Opposite_Teacher_546 🔥Cheap Lifetime Spotify Premium On Your Account!🔥
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2023.05.28 15:44 Opposite_Teacher_546 🔥Cheap Lifetime Spotify Premium On Your Account!🔥
Lifetime Spotify Premium On Your Account ! 📣HURRY THERE IS ONLY 20 KEYS LEFT!📣
✅ Over 20+ Happy customers
✅ 5 Stars
✅ Quick Process (5 minutes max)
✅ As Cheap As A Monthly Subscription
✅ Instant Delivery Of Your Key
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🔥 What are you waiting for? Stop Spending 10 dollars a month and pay 10 dollars for LIFETIME!!! 🔥
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2023.05.28 15:44 erock255555 Advice on high end PC build for gaming
Long story short is I wasn't planning on upgrading my 12 year old built PC but my wife surprised me with a RTX 4090 gfx card because she knew I wouldn't spend the money myself. Now I've got a top of the line card and do not have the technical know how to build a functioning PC around it. PCPartPickerBuild
is the build that I'm working off of and the computer will be used for most standard gaming but also plan on getting tethered VR headset to play Elite Dangerous in VR and hopefully find more games that work well with tethered VR. Are there any problems with the listed build? I've been browsing potential builds and I see water cooling in a lot of them and wondering if I'm missing out on that. I'm also wondering if there are any $100 upgrades here and there I could make that would be worth it like getting a better case (for cooling?) or should I upgrade the CPU to 16 cores? If you had +$600 to work with the listed build, what would you add for a gaming PC?
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2023.05.28 15:44 swagmasternelly AITA for calling out of work?
calling out of work always feels like the worst thing in the world. I am literally throwing up, nauseous, & I didn’t sleep at all… but I still feel like the worst human in the world for calling out. i’m a nanny, so the mom does rely on me to be there so she can go to her job. I am also pretty notorious for calling out for being sick, but I don’t lie about it. I am actually sick or not feeling good. but it is like once a week, im not sure what to do & im probably gonna get fired.
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2023.05.28 15:44 Lhord_Stevenson13 Parents not with me on how to give assignments.
Hi um, this is sorta a rant and also seeking second and third opinions on an issue that has had more of a negative impact on me than I thought it would...
(Some context)... I have made a few posts asking for help on how to do some stuff in my class and I have found actual help here on this subreddit. However this is different. I'm not asking for advice, I'm asking for blunt opinions.
I would have liked to start from last year... but I guess we all don't have time. Anyway, This academic year started rough; There's a restructuring of the academic calendar and that means we have shorter terms... That's besidesl the point. If it's taking too long for me to get to it already, I'm sorry buh, let me take my time.
I'm not in The Americas or Europe. I'm in Ghana, Africa. Our education system might be a little different from most of yours but, generally there's not much difference.
I have tried my all to make my class (grade two) separate from all others. My class is special, not because I'm saying so, but because many say so .
(I'm going straight to the point now, I promise) Okay, so this is all about the stuff I teach and assignments I give to my kids to send home.
I teach what I am given (scheme of work is what we call it, based on the syllabus) but in the way that I find best. Because I am the class teacher, and that is what class teachers do.
I am a really young guy, as young as I can legally be. And I'm really passionate about what I do because I know I am building the foundation of our future generation and I'm really careful about how I go about teaching.
I created a parents and teacher forum (the first of its kind in my school) on WhatsApp, so I can have direct interaction with parents and relay any info to them. All was going smoothly until one one the 'learned' parents started questioning what I teach my kids.
At first, I didn't take it too seriously, because I did explain to them that I can not teach just whatever I want, and I go by the curriculum (bla, bla, bla).
This parent still would not budge. And soon enough, he got a few parents to back him up. But I wasn't worried at all. Because any complaints made to the management would be looked at and nullified, since it would be confirmed that I do not teach what I want to, but go by what I've been given.
The second issue was how I set my assignments for (or homework as we call it). I would like to say that, I consider myself an intellectual, whose actions are based on his own philosophy, created wholly by him or borrowed from others. I know I'm an intellectual, but I also know I do not and can not know everything about everything (it's not like I don't try). I have sacrificed many things to become who I am and I do not regret it one bit. So if I seem a little too condescending or full of myself, maybe that's why.
Or maybe it's because I'm angry cos I feel like something is being taken away from me...
Anyway, when I was appointed my current position last year, I decided on changing a few things, and that included the manner in which I give assignments. I used to give multiple choice questions as homework, but I changed that quickly and here's my reasoning:
Learning does not end in school. And as kids, they need to spend a greater part of their day learning. That doesn't mean they should not play (God forbid I say anything as such). Children literally need to play, spend time with their friends, watch TV and stuff. But I know for a fact that most of my kids do not learn at home. Most come to school, play, go home and play some more. So I decided that if parents would not work on that, then I would. After all, I have been getting complaints from many of these parents that their kids do not learn at home.
What I did was to give questions without options. Thus, for example;
COMPUTING Homework State the functions of the following
OR HISTORY Homework Answer the following correctly
- Okomfo Anokye Sword Site is in what hospital?
- The hospital is in what town?
- What is planted in the ground?
- Who planted the sword?
- If the sword is pulled out, what would happen?
This (I thought) would maximise lesson periods in the house, since homework time would be the only time most of them would actually take a book. These kids can't read (I know) so the one who helped them with homeworks should sit them down, ask them questions and them guide them in writing the answers they (the kids) give. In this way, parents should be able to know the progress of their kids in lessons and whether or not they comprehend what is being taught them.
But apparently I thought wrong (at least that's how it seems). I don't know if the complaints started this term or not... But I didn't get any, and if the principal did, then he's not been telling me.
Parents are saying my homeworks are too difficult and even junior high schoolers can't find solutions to them. This made me very distraught cos what I thought was a service has turned into a disservice.
It hurt me deeply because I love my class and I try everything in my little power to do the best for them.
If you have anything to tell me, say it bluntly. For I am one who does not think that truth should be padded. I might not be able to answer immediately, but I will. And if you need any clarification, just ask.
As I said, this is a rant and I most definitely have left some things out...
Thank you very much.
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2023.05.28 15:44 MatejX Option to adit time of a record/tree?
Hello! I often A) forget that that my tree is still growing when I am not focusing anymore or B) forget to plant it in the first place. There doesn't seem to be an option to edit time spent on a tree and even if I wither it, it still counts the time spent on planting it as productive. The only way to get rid of the time is to pay for it, and the price seems to be much higher than what I got from planting it. When I do need to focus on something, I often work for a couple of hours straight, so my settings are set to let the tree grow up to 180 minutes. It is incredibly frustrating when I end up with 3 hours long records which shouldn't be there because I've planted a tree and completely forgot about it.
Everything else about the Forest is great, and this is the one thing that is really ruining the experience for me (well not really, I still very much enjoy the Forest app). Is there really no way of editing the records? Does anyone have a similar experience and knows if there is a way to request features for the app and move them up the priority list? I have sent feedback to the developers in the past, but I don't think I've had any response from them & don't know if they even have time to read feedback.
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